Okubo M, Nagura Y, Pompa D, Treser G, Lange K
Ann Rheum Dis. 1977 Oct;36(5):433-41. doi: 10.1136/ard.36.5.433.
A leucocyte migration inhibition test was performed on 26 patients with systemic lupus erythematosus (SLE) and on 35 control subjects using three different antigens, fetal calf thymus DNA, baker's yeast RNA, and calf thymus extractable nuclear antigen (ENA). Leucocyte migration was inhibited by DNA in 17 out of 26 SLE patients (65-3%), and in only 2 of the 35 controls (5-7%). When RNA or ENA was added none of the patients or controls showed inhibition. In SLE patients migration inhibition by DNA was significantly correlated with the presence of proteinuria and/or granular casts in urinary sediment. When the migration inhibition test was positive, immunofluorescence verified active histology of the glomeruli obtained by a percutaneous renal biopsy.
对26例系统性红斑狼疮(SLE)患者和35名对照者进行了白细胞迁移抑制试验,使用三种不同的抗原:胎牛胸腺DNA、面包酵母RNA和小牛胸腺可提取核抗原(ENA)。26例SLE患者中有17例(65.3%)的白细胞迁移受到DNA抑制,而35名对照者中只有2例(5.7%)受到抑制。当加入RNA或ENA时,患者和对照者均未出现抑制现象。在SLE患者中,DNA引起的迁移抑制与尿沉渣中蛋白尿和/或颗粒管型的存在显著相关。当迁移抑制试验呈阳性时,免疫荧光证实经皮肾活检获得的肾小球有活跃的组织学改变。