Lozman J, Dutton R E, Newell J, Powers S R
Ann Surg. 1977 Nov;186(5):607-13. doi: 10.1097/00000658-197711000-00011.
Ventilatory function of the lungs has been studied in 13 post-trauma patients using a two compartment analysis. The analysis is based upon a model of the lung which describes a nitrogen washout curve in terms of fast and slowly ventilated compartments. Data output from a digital computer provides values that compare the fractions of the alveolar ventilation and volume of the two compartments. All patients on initial investigation had large identifiable slow spaces. Subsequent evaluation at a time of clinical improvement showed that the ventilation of the slow space had increased significantly (P less than .003), whereas no change was evident in the volume fraction. The ventilation to volume ratio of the slow space, measured on these two separate occasions increased in twelve of the patients studied. An increase in this ratio correlated with improvement in the patient's clinical condition.
采用两室分析法对13例创伤后患者的肺通气功能进行了研究。该分析基于一个肺模型，该模型根据快速通气和缓慢通气的肺区来描述氮气洗脱曲线。数字计算机输出的数据提供了比较两个肺区的肺泡通气分数和容积的值。所有患者在初始检查时都有明显的大的缓慢肺区。临床病情改善时的后续评估显示，缓慢肺区的通气显著增加（P小于0.003），而容积分数无明显变化。在这两个不同时间点测量的缓慢肺区的通气/容积比在12例研究患者中有所增加。该比值的增加与患者临床病情的改善相关。
