• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

4-hydroxynonenal-induced relaxation of human mesenteric arteries.

作者信息

Romero F J, Romero M J, Bosch-Morell F, Martínez M C, Medina P, Lluch S

机构信息

Department of Physiology, School of Medicine & Dentistry, University of Valencia, Spain.

出版信息

Free Radic Biol Med. 1997;23(3):521-3. doi: 10.1016/s0891-5849(97)00119-6.

DOI:10.1016/s0891-5849(97)00119-6
PMID:9214591
Abstract

The effect of 4-hydroxynonenal (4-HNE), a circulating lipid peroxidation product, on the vascular tone of human mesenteric arteries is studied. 4-HNE promotes relaxation of human mesenteric arterial rings in a concentration-dependent manner. Removal of the endothelium or treatment with N(G)-nitro-L-arginine methyl ester hydrochloride (L-NAME; 10(-4) M) partially prevented 4-HNE-induced relaxation, thus suggesting the intervention of nitric oxide from endothelial origin in the vascular effects of 4-HNE.

摘要

相似文献

1
4-hydroxynonenal-induced relaxation of human mesenteric arteries.
Free Radic Biol Med. 1997;23(3):521-3. doi: 10.1016/s0891-5849(97)00119-6.
2
4-Hydroxynonenal, a lipid peroxidation product, induces relaxation of human cerebral arteries.4-羟基壬烯醛，一种脂质过氧化产物，可诱导人脑动脉舒张。
J Cereb Blood Flow Metab. 1994 Jul;14(4):693-6. doi: 10.1038/jcbfm.1994.87.
3
Control of mesenteric arterial tone in vitro in humans and rats.人体和大鼠肠系膜动脉张力的体外控制
Naunyn Schmiedebergs Arch Pharmacol. 1999 Apr;359(4):322-30. doi: 10.1007/pl00005358.
4
The influence of chronic inhibition of nitric oxide synthesis on contractile and relaxant properties of rat carotid and mesenteric arteries.一氧化氮合成的慢性抑制对大鼠颈动脉和肠系膜动脉收缩和舒张特性的影响。
Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):504-11. doi: 10.1007/s002100000254.
5
Endothelial nitric oxide modulates perivascular sensory neurotransmission in the rat isolated mesenteric arterial bed.内皮型一氧化氮调节大鼠离体肠系膜动脉床的血管周围感觉神经传递。
Br J Pharmacol. 2002 Sep;137(1):19-28. doi: 10.1038/sj.bjp.0704837.
6
Endothelium-dependent modulation of resistance vessel contraction: studies with NG-nitro-L-arginine methyl ester and NG-nitro-L-arginine.阻力血管收缩的内皮依赖性调节：使用NG-硝基-L-精氨酸甲酯和NG-硝基-L-精氨酸的研究
Br J Pharmacol. 1992 Oct;107(2):616-21. doi: 10.1111/j.1476-5381.1992.tb12792.x.
7
Carbon dioxide induced vasorelaxation in rat mesenteric small arteries precontracted with noradrenaline is endothelium dependent and mediated by nitric oxide.二氧化碳诱导去甲肾上腺素预收缩的大鼠肠系膜小动脉舒张，这种舒张依赖于内皮细胞，且由一氧化氮介导。
Pflugers Arch. 1993 May;423(3-4):343-5. doi: 10.1007/BF00374415.
8
Role of the endothelium in the relaxation induced by propofol and thiopental in isolated arteries from man.内皮在丙泊酚和硫喷妥钠诱导的人体离体动脉舒张中的作用。
J Pharm Pharmacol. 1997 Apr;49(4):430-2. doi: 10.1111/j.2042-7158.1997.tb06819.x.
9
Arterial contractions induced by cumulative addition of calcium in hypertensive and normotensive rats: influence of endothelium.钙累积添加对高血压和正常血压大鼠动脉收缩的影响：内皮的作用
Naunyn Schmiedebergs Arch Pharmacol. 1994 Jun;349(6):627-36. doi: 10.1007/BF01258469.
10
Relaxant effects of carbon monoxide compared with nitric oxide in pulmonary and systemic vessels of newborn piglets.新生仔猪肺血管和体循环血管中一氧化碳与一氧化氮舒张作用的比较
Pediatr Res. 2000 Oct;48(4):546-53. doi: 10.1203/00006450-200010000-00021.

引用本文的文献

1
The Mito-Hormetic Mechanisms of Ozone in the Clearance of SARS-CoV2 and in the COVID-19 Therapy.臭氧在清除新冠病毒及治疗新冠肺炎中的线粒体应激机制
Biomedicines. 2022 Sep 12;10(9):2258. doi: 10.3390/biomedicines10092258.
2
Acrolein but not its metabolite, 3-Hydroxypropylmercapturic acid (3HPMA), activates vascular transient receptor potential Ankyrin-1 (TRPA1): Physiological to toxicological implications.丙烯醛会激活血管瞬态受体电位锚蛋白 1（TRPA1），而其代谢物 3-羟基丙硫基尿酸（3HPMA）则不会：生理到毒理学意义。
Toxicol Appl Pharmacol. 2021 Sep 1;426:115647. doi: 10.1016/j.taap.2021.115647. Epub 2021 Jul 13.
3
Crotonaldehyde-induced vascular relaxation and toxicity: Role of endothelium and transient receptor potential ankyrin-1 (TRPA1).
丁烯醛诱导的血管舒张和毒性：内皮细胞和瞬时受体电位锚蛋白 1（TRPA1）的作用。
Toxicol Appl Pharmacol. 2020 Jul 1;398:115012. doi: 10.1016/j.taap.2020.115012. Epub 2020 Apr 19.
4
Formaldehyde Induces Mesenteric Artery Relaxation via a Sensitive Transient Receptor Potential Ankyrin-1 (TRPA1) and Endothelium-Dependent Mechanism: Potential Role in Postprandial Hyperemia.甲醛通过敏感的瞬时受体电位锚蛋白1（TRPA1）和内皮依赖性机制诱导肠系膜动脉舒张：在餐后充血中的潜在作用
Front Physiol. 2019 Mar 28;10:277. doi: 10.3389/fphys.2019.00277. eCollection 2019.
5
Acute cardiopulmonary toxicity of inhaled aldehydes: role of TRPA1.吸入醛类的急性心肺毒性：瞬时受体电位锚蛋白1的作用
Ann N Y Acad Sci. 2016 Jun;1374(1):59-67. doi: 10.1111/nyas.13055. Epub 2016 May 6.
6
Effects of 4-hydroxynonenal on vascular endothelial and smooth muscle cell redox signaling and function in health and disease.4-羟基壬烯醛对健康与疾病状态下血管内皮细胞和平滑肌细胞氧化还原信号传导及功能的影响
Redox Biol. 2013 May 23;1(1):319-31. doi: 10.1016/j.redox.2013.04.001.
7
Acrolein induces vasodilatation of rodent mesenteric bed via an EDHF-dependent mechanism.丙烯醛通过一种依赖于内皮衍生超极化因子（EDHF）的机制诱导啮齿动物肠系膜床血管舒张。
Toxicol Appl Pharmacol. 2006 Dec 15;217(3):266-76. doi: 10.1016/j.taap.2006.08.008. Epub 2006 Aug 26.
8
Lipid peroxidation products and antioxidants in human disease.人类疾病中的脂质过氧化产物与抗氧化剂
Environ Health Perspect. 1998 Oct;106 Suppl 5(Suppl 5):1229-34. doi: 10.1289/ehp.98106s51229.