Kim H C, Khanwilkar P S, Bearnson G B, Olsen D B
Artificial Heart Research Laboratory, Seoul National University, Korea.
IEEE Trans Biomed Eng. 1997 Jan;44(1):77-89. doi: 10.1109/10.553715.
An automatic physiological control system for the actively filled, alternately pumped ventricles of the volumetrically coupled, electrohydraulic total artificial heart (EHTAH) was developed for long-term use. The automatic control system must ensure that the device: 1) maintains a physiological response of cardiac output, 2) compensates for an nonphysiological condition, and 3) is stable, reliable, and operates at a high power efficiency. The developed automatic control system met these requirements both in vitro, in week-long continuous mock circulation tests, and in vivo, in acute open-chested animals (calves). Satisfactory results were also obtained in a series of chronic animal experiments, including 21 days of continuous operation of the fully automatic control mode, and 138 days of operation in a manual mode, in a 159-day calf implant.
开发了一种用于容积耦合式电动液压全人工心脏（EHTAH）主动充盈、交替泵血心室的自动生理控制系统，以实现长期使用。该自动控制系统必须确保该装置：1）维持心输出量的生理反应，2）补偿非生理状况，3）稳定、可靠且以高功率效率运行。所开发的自动控制系统在体外长达一周的连续模拟循环测试以及体内急性开胸动物（小牛）实验中均满足了这些要求。在一系列慢性动物实验中也获得了满意的结果，包括在159天的小牛植入实验中，全自动控制模式连续运行21天，手动模式运行138天。
