Westermark P
Acta Derm Venereol. 1979;59(4):341-5.
Skin biopsies from patients with different forms of localized and systemic amyloidoses were studied. Subepidermal deposits, typical of lichen amyloidosus, were also seen in other types of amyloidosis, least frequent in the secondary systemic form. Amyloid within the epidermis and especially the horny layer as well as pigmented cells close to the deposits were found in all cases of lichen amyloidosus but in no other specimens. Plasma cells, on the other hand, were numerous in nodular amyloidosis but were not found in any other cases. It is concluded that in the pathogenesis of lichen amyloidosus the epidermis and perhaps dermal melanocytes are involved. In the pathogenesis of localized nocular amyloidosis the plasma cells might be of importance.
对患有不同形式的局限性和全身性淀粉样变性的患者进行了皮肤活检研究。苔藓样淀粉样变典型的表皮下沉积物在其他类型的淀粉样变性中也可见，在继发性全身性淀粉样变中最少见。在所有苔藓样淀粉样变病例中均发现表皮内尤其是角质层以及沉积物附近的色素细胞中有淀粉样物质，但在其他标本中未发现。另一方面，浆细胞在结节性淀粉样变中数量众多，但在其他任何病例中均未发现。得出的结论是，在苔藓样淀粉样变的发病机制中，表皮以及可能的真皮黑素细胞参与其中。在局限性结节性淀粉样变的发病机制中，浆细胞可能具有重要意义。
