Ansink A C, Cross P A, Scorer P, de Barros Lopes A, Monaghan J M
Queen Elizabeth Hospital, Gateshead, Tyne and Wear, United Kingdom.
J Clin Pathol. 1997 Apr;50(4):328-31. doi: 10.1136/jcp.50.4.328.
To investigate the role of oestrogen and progesterone receptor status in uterine carcinosarcomas (mixed Müllerian tumours) to see whether the receptors were identifiable, and if so whether they were of significance clinically.
11 cases of uterine carcinosarcoma were identified from clinical and pathology records. An immunohistochemical method was used to demonstrate oestrogen and progesterone hormone receptors on paraffin embedded material, with suitable tissue controls, staining being recorded.
10 of 11 cases showed staining for one or both hormone receptors in normal tissue adjacent to tumour. In four carcinosarcoma cases, staining for one or both receptors was shown within the epithelial component (appearing to correlate with the degree of epithelial differentiation); two of these cases had staining within sarcomatous areas. Two of the three patients still alive had epithelial hormone receptor positivity.
Receptors for oestrogen and progesterone were found in four of 11 cases of uterine carcinosarcoma, using paraffin embedded material. There may be an association between hormone receptor positivity and clinical outcome.
研究雌激素和孕激素受体状态在子宫癌肉瘤（混合性苗勒管肿瘤）中的作用，以确定这些受体是否可被识别，若可识别，其在临床上是否具有重要意义。
从临床和病理记录中识别出11例子宫癌肉瘤病例。采用免疫组织化学方法在石蜡包埋材料上显示雌激素和孕激素受体，并设置合适的组织对照，记录染色情况。
11例病例中有10例在肿瘤邻近的正常组织中显示一种或两种激素受体染色。在4例癌肉瘤病例中，上皮成分内显示一种或两种受体染色（似乎与上皮分化程度相关）；其中2例在肉瘤区域内有染色。3例存活患者中有2例上皮激素受体呈阳性。
使用石蜡包埋材料，在11例子宫癌肉瘤中有4例发现雌激素和孕激素受体。激素受体阳性与临床结局之间可能存在关联。
