Munson J B, McMahon S B
Department of Physiology, St Thomas' Hospital Medical School, London, UK.
Eur J Neurosci. 1997 Jun;9(6):1126-9. doi: 10.1111/j.1460-9568.1997.tb01465.x.
Glial cell-line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor shown to rescue developing and adult motoneurons in vitro and in vivo from programmed and injury-induced cell death. To test whether GDNF would rescue adult mammalian sensory and motor neurons from physiological consequences of injury, the tibial nerve of rats was axotomized and, after a 10 day delay to permit injury processes to proceed, vehicle or GDNF was supplied directly to the nerve for 2 or 4 weeks or GDNF intrathecally for 2 weeks. Conduction velocity (CV) of both sensory and motor axons declined during the initial 10 days, and even more so if then treated with vehicle. Treatment with GDNF resulted in marginal improvement of sensory axon CV. CV of motor axons recovered significantly in a dose- and time-dependent manner. The results suggest that GDNF may have therapeutic potential in the treatment of peripheral neuropathies.
胶质细胞源性神经营养因子（GDNF）是一种强效神经营养因子，已证明其在体外和体内可挽救发育中的和成年的运动神经元，使其免于程序性死亡和损伤诱导的细胞死亡。为了测试GDNF是否能挽救成年哺乳动物的感觉和运动神经元免受损伤的生理后果影响，将大鼠的胫神经进行轴突切断，在延迟10天以允许损伤过程进展后，将载体或GDNF直接施用于神经2周或4周，或将GDNF鞘内注射2周。感觉和运动轴突的传导速度（CV）在最初的10天内下降，如果随后用载体治疗则下降得更明显。用GDNF治疗导致感觉轴突CV略有改善。运动轴突的CV以剂量和时间依赖性方式显著恢复。结果表明，GDNF在治疗周围神经病变方面可能具有治疗潜力。
