Kim S J, Shiba E, Ishii H, Inoue T, Taguchi T, Tanji Y, Kimoto Y, Izukura M, Takai S
Department of Surgical Oncology, Osaka University Medical School, Japan.
Anticancer Res. 1997 May-Jun;17(3C):2319-23.
Thrombomodulin (TM) is a natural anticoagulant which inhibits thrombin. Recent studies have reported that TM is correlated with vascular diseases and a few cancers. The aim of this study was to evaluate the role and the prognostic value of TM in breast cancer.
TM expression in samples from 60 invasive breast cancer patients was examined immunohistochemically with a polyclonal antibody against TM.
TM staining was observed mainly on both the cytoplasm and cell surface in cancer cells and on endothelial cells around or in cancer tissue. TM expression in cancer cells was not correlated with the clinicopathological features. However, low TM expression was significantly correlated with a high relapse rate (p = 0.047 by the chi 2 test and 0.05 by the Kaplan-Meier method).
TM might play an active role in cancer invasion and metastasis, and serve as a new prognostic factor in invasive breast cancer.
血栓调节蛋白（TM）是一种抑制凝血酶的天然抗凝剂。最近的研究报道，TM与血管疾病和一些癌症相关。本研究的目的是评估TM在乳腺癌中的作用及预后价值。
用抗TM的多克隆抗体通过免疫组织化学方法检测60例浸润性乳腺癌患者样本中的TM表达。
在癌细胞的细胞质和细胞表面以及癌组织周围或内部的内皮细胞上均观察到TM染色。癌细胞中的TM表达与临床病理特征无关。然而，低TM表达与高复发率显著相关（卡方检验p = 0.047，Kaplan-Meier法p = 0.05）。
TM可能在癌症侵袭和转移中发挥积极作用，并可作为浸润性乳腺癌的一个新的预后因素。
