Sinke R J, Dijkhuizen T, Janssen B, Olde Weghuis D, Merkx G, van den Berg E, Schuuring E, Meloni A M, de Jong B, Geurts van Kessel A
Department of Human Genetics, University Hospital, Nijmegen, The Netherlands.
Cancer Genet Cytogenet. 1997 Jul 15;96(2):95-101. doi: 10.1016/s0165-4608(96)00250-6.
Recent cytogenetic analysis of a series of human renal oncocytomas revealed the presence of a recurring chromosomal translocation (5;11)(q35;q13) as sole anomaly in a subset of the tumors. The molecular characterization of this translocation was initiated using two primary t(5;11)-positive renal oncocytomas and a panel of somatic cell hybrids derived from one of these tumors, in conjunction with fluorescence in situ hybridization (FISH) and Southern blot analysis. The breakpoint in chromosome band 11q13 could be located within a genomic interval of at maximum 400 Kb immediately centromeric to the BCL1 locus.
