Gürdal-Yüksel E, Karadağ M, Ozyardimci N, Kunt-Uzaslan A E, Yarkin T
Department of Chest Diseases, Uludağ University School of Medicine, Bursa, Turkey.
J Environ Pathol Toxicol Oncol. 1996;15(2-4):161-7.
The purpose of our study was to evaluate the effects of cigarette smoking and serum lipids, folate, and vitamin B12 on the development of lung cancer in the Turkish population. The study group consisted of patients with histologically proven lung cancer and the control group comprised healthy smokers being followed in our smoking cessation outpatient department. Smoking history was obtained from all subjects and serum total cholesterol, HDL cholesterol, triglycerides, vitamin B12, and folate levels were measured. Pack/years of cigarettes smoked were significantly higher in the subjects with lung cancer than in the control group (p < 0.01). Serum total cholesterol, HDL cholesterol, triglyceride, serum folate, and vitamin B12 levels were within normal limits in both groups (p < 0.05), but serum vitamin B12 levels were statistically significantly higher (p < 0.01) in the cancer group than in the controls. In our study, we did not observe low levels of serum cholesterol, vitamin B12, or folate in the lung cancer patients.
我们研究的目的是评估吸烟、血清脂质、叶酸和维生素B12对土耳其人群肺癌发生的影响。研究组由组织学确诊的肺癌患者组成，对照组包括在我们戒烟门诊部接受随访的健康吸烟者。记录所有受试者的吸烟史，并检测血清总胆固醇、高密度脂蛋白胆固醇、甘油三酯、维生素B12和叶酸水平。肺癌患者的吸烟包年数显著高于对照组（p<0.01）。两组的血清总胆固醇、高密度脂蛋白胆固醇、甘油三酯、血清叶酸和维生素B12水平均在正常范围内（p<0.05），但癌症组的血清维生素B12水平在统计学上显著高于对照组（p<0.01）。在我们的研究中，未观察到肺癌患者血清胆固醇、维生素B12或叶酸水平较低的情况。
