Lackner H, Urban C, Kerbl R, Schwinger W, Beham A
Department of Pediatrics, University of Graz, Austria.
Cancer. 1997 Jul 15;80(2):334-40. doi: 10.1002/(sici)1097-0142(19970715)80:2<334::aid-cncr22>3.0.co;2-u.
Antiestrogens and nonsteroidal antiinflammatory drugs have been shown to be effective in adult patients with unresectable or recurrent desmoid tumors. It appears that the growth of these tumors is influenced by estrogen, and that antiestrogen treatment may inhibit further proliferation of tumor cells. Nonsteroidal antiinflammatory drugs are thought to be effective through their interference with prostaglandin metabolism.
Two children with unresectable desmoid tumors (aggressive fibromatosis) were treated with tamoxifen (1 mg/kg orally, twice daily) and diclofenac (2 mg/kg rectally, twice daily).
At last follow-up, tumor regression and growth arrest were maintained for more than 51 months in 1 child with rapidly growing recurrent fibromatosis of the thoracic wall. Another child with an inoperable desmoid tumor of the submandibular region had stable disease since the initiation of treatment.
This is the first report describing this treatment approach in childhood fibromatosis. Combined therapy with endocrine therapy and nonsteroidal antiinflammatory drugs may be a nonaggressive alternative to chemotherapy and radiotherapy in the treatment of children with inoperable desmoid tumors.
抗雌激素药物和非甾体类抗炎药已被证明对不可切除或复发性硬纤维瘤成年患者有效。这些肿瘤的生长似乎受雌激素影响，抗雌激素治疗可能抑制肿瘤细胞的进一步增殖。非甾体类抗炎药被认为通过干扰前列腺素代谢而发挥作用。
两名患有不可切除硬纤维瘤（侵袭性纤维瘤病）的儿童接受了他莫昔芬（口服1毫克/千克，每日两次）和双氯芬酸（直肠给药2毫克/千克，每日两次）治疗。
在最后一次随访时，1名患有快速生长的胸壁复发性纤维瘤病的儿童，肿瘤消退和生长停滞持续超过51个月。另一名患有下颌下区不可切除硬纤维瘤的儿童自治疗开始以来病情稳定。
这是首篇描述儿童纤维瘤病这种治疗方法的报告。内分泌治疗和非甾体类抗炎药联合治疗可能是治疗不可切除硬纤维瘤病儿童的一种非激进的化疗和放疗替代方法。
