Tanaka M, Zhen Y X, Tagami H
Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan.
Br J Dermatol. 1997 Jun;136(6):966-7.
Patients with atopic dermatitis (AD) constantly inflict mechanical damage to their skin by scratching induced by pruritus. On excoriated lesions of the cheek we found exceedingly high levels of transepidermal water loss (TEWL) as compared to those in the normal skin of healthy subjects. However, it is not clear whether the skin of patients with AD also shows an abnormally slow recovery after mechanical damage. We compared the recovery of the barrier function of the stratum corneum (SC), after its complete removal by tape stripping, in patients with AD and age-matched healthy control subjects. On the normal-looking skin of the flexor forearm, we found no difference in the recovery process of the water barrier function of the SC between the two groups. This suggests that ability to reconstruct SC barrier function after mechanical damage is not impaired in AD patients.
特应性皮炎（AD）患者会因瘙痒引起的搔抓而不断对其皮肤造成机械性损伤。在脸颊的擦伤性皮损处，我们发现与健康受试者的正常皮肤相比，经表皮水分流失（TEWL）水平极高。然而，尚不清楚AD患者的皮肤在机械损伤后是否也表现出异常缓慢的恢复情况。我们比较了AD患者和年龄匹配的健康对照受试者在通过胶带剥离完全去除角质层（SC）后，角质层屏障功能的恢复情况。在屈侧前臂外观正常的皮肤上，我们发现两组之间SC水分屏障功能的恢复过程没有差异。这表明AD患者在机械损伤后重建SC屏障功能的能力并未受损。
