Gitlin J D, Gitlin J I, Gitlin D
Arthritis Rheum. 1977 Nov-Dec;20(8):1491-9. doi: 10.1002/art.1780200808.
Synovial biopsies from 8 patients with rheumatoid arthritis, 2 patients with degenerative osteoarthritis, and 4 patients with nonarthritic disease were studied for localization of C-reactive protein (CRP) using immunofluorescence microscopy. The nuclei of many synoviocytes and histiocytes in rheumatoid synovial membrane were found to bind CRP. Cultures of rheumatoid synovium in 14C-labeled amino acids produced radioactive IgG, IgM, IgA, and C3; but not CRP, indicating the synovial-bound CRP was not of local origin. A few CRP-binding nuclei were present in one osteoarthritis synovium, but none was found in the other and none in synovium from the 4 nonarthritis patients. The nature of the nuclear CRP ligand in rheumatoid synovium was not determined.
对8例类风湿性关节炎患者、2例退行性骨关节炎患者以及4例非关节炎疾病患者的滑膜活检组织进行研究，采用免疫荧光显微镜技术定位C反应蛋白（CRP）。结果发现，类风湿滑膜中许多滑膜细胞和组织细胞的细胞核能够结合CRP。用14C标记氨基酸培养类风湿滑膜，可产生放射性IgG、IgM、IgA和C3，但未产生CRP，这表明滑膜结合的CRP并非源自局部。在1例骨关节炎滑膜中有少量CRP结合细胞核，而在另1例骨关节炎滑膜以及4例非关节炎患者的滑膜中均未发现。类风湿滑膜中细胞核CRP配体的性质尚未明确。
