通过琼脂扩散沉淀反应证明1型脊髓灰质炎病毒各毒株之间的抗原差异。
Demonstration of antigenic differences between strains of poliovirus type 1 by agar diffusion precipitation reaction.
作者信息
Savinskaya S S, Shekoyan L A, Shirman G A
出版信息
Acta Virol. 1979 May;23(3):183-8.
Antigenic differences between type 1 poliovirus strains circulating in nature were investigated by agar diffusion precipitation reaction. Three strain-specific sera were absorbed with antigens prepared from 8 strains (Sabin's vaccine strain LSc2ab and 7 strains isolated from poliomyelitis patients or healthy persons). The results suggested the presence of at least 5 antigenic determinants in the poliovirus type 1 strains studied. Three determinants in different combinations were found in 7 strains and 2 determinants were found in 1 strain. It is assumed that antigenic differences among poliovirus strains may be due to different combinations of several antigenic determinants.
通过琼脂扩散沉淀反应研究了自然界中流行的1型脊髓灰质炎病毒株之间的抗原差异。用从8株病毒（萨宾疫苗株LSc2ab以及从脊髓灰质炎患者或健康人分离出的7株病毒）制备的抗原吸收三种菌株特异性血清。结果表明，在所研究的1型脊髓灰质炎病毒株中至少存在5个抗原决定簇。在7株病毒中发现了三种不同组合的决定簇，在1株病毒中发现了2个决定簇。据推测，脊髓灰质炎病毒株之间的抗原差异可能是由于几种抗原决定簇的不同组合所致。
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