Oyama T, Toyota M, Shinozaki Y, Kudo T
Br J Anaesth. 1977 Oct;49(10):983-90. doi: 10.1093/bja/49.10.983.
Thirty patients received morphine and 27 received ketamine. Morphine anaesthesia did not influence plasma concentrations of luteinizing hormone (LH) significantly, but there was a significant increase during ketamine anaesthesia. Plasma LH increased in the early stage of surgery under both anaesthetics. A significant decrease in the plasma concentration of testosterone was found during and following both techniques of anaesthesia, the lowest concentration being detected on the first day after surgery. Ketamine anaesthesia, but not morphine, stimulated adrenocortical function significantly. Furhter stimulation was detected in the periods during and after operation with both anaesthetic techniques.
30名患者接受了吗啡治疗，27名患者接受了氯胺酮治疗。吗啡麻醉对促黄体生成素（LH）的血浆浓度没有显著影响，但氯胺酮麻醉期间LH显著升高。在两种麻醉方式下，手术早期血浆LH均升高。在两种麻醉技术实施期间及之后，均发现睾酮血浆浓度显著下降，最低浓度在术后第一天检测到。氯胺酮麻醉而非吗啡麻醉显著刺激肾上腺皮质功能。在手术期间及术后，两种麻醉技术均检测到进一步的刺激作用。
