手术及硬膜外或全身麻醉对青春期前男孩血浆睾酮、17-羟孕酮和皮质醇水平的影响。

Effects of surgery and epidural or general anaesthesia on testosterone, 17-hydroxyprogesterone and cortisol plasma levels in prepubertal boys.

作者信息

Boninsegni R, Salerno R, Giannotti P, Andreuccetti T, Busoni P, Santoro S, Forti G

出版信息

J Steroid Biochem. 1983 Dec;19(6):1783-7. doi: 10.1016/0022-4731(83)90360-6.

Abstract

Testosterone (T), 17-hydroxyprogesterone (17P) and cortisol (F) plasma levels have been measured in two groups of prepubertal boys before and during surgery under general anaesthesia (Group 1) and epidural anaesthesia (Group 2) respectively. The mean plasma levels of T, 17P and F increased significantly (P less than 0.05; P less than 0.001; P less than 0.005, respectively) during surgery in Group 1; in Group 2 the plasma levels of T and F did not show any significant variation, whereas 17P significantly increased (P less than 0.05). However the mean level reached by 17P in Group 2 was significantly lower (P less than 0.005) than that observed in Group 1. No significant variation of LH and FSH plasma levels was observed in either group. Our report suggests that the modifications of T and 17P plasma levels observed during surgery under general anaesthesia (GA) are probably due to the stress induced adrenal response. This response can be inhibited or reduced by epidural anaesthesia (EA).

摘要

分别在两组青春期前男孩全身麻醉手术前及手术过程中（第1组）和硬膜外麻醉手术前及手术过程中（第2组）测量了血浆睾酮（T）、17 - 羟孕酮（17P）和皮质醇（F）水平。第1组手术期间，T、17P和F的平均血浆水平显著升高（分别为P < 0.05；P < 0.001；P < 0.005）；第2组中，T和F的血浆水平未显示任何显著变化，而17P显著升高（P < 0.05）。然而，第2组中17P达到的平均水平显著低于第1组（P < 0.005）。两组中促黄体生成素（LH）和促卵泡激素（FSH）的血浆水平均未观察到显著变化。我们的报告表明，全身麻醉（GA）手术期间观察到的T和17P血浆水平变化可能归因于应激诱导的肾上腺反应。这种反应可被硬膜外麻醉（EA）抑制或减轻。