Oyama T, Taniguchi K, Ishihara H, Matsuki A, Maeda A, Murakawa T, Kudo T
Acta Anaesthesiol Scand Suppl. 1979;71:32-8. doi: 10.1111/j.1399-6576.1979.tb05470.x.
Forty-five patients underwent enflurane anaesthesia and surgery. Anaesthesia alone evoked little change in the plasma concentrations of ACTH, cortisol or antidiuretic hormone (ADH), but there were significant increases during surgery. The plasma levels of aldosterone rose during anaesthesia alone, and a further increase was noted during surgery. Neither enflurane anaesthesia nor surgery significantly influenced plasma concentrations of renin activity and thyroxine. A significant decrease in the plasma triiodothyronine levels was detected during anaesthesia alone, and a further decrease was found during and following surgery. Enflurane anaesthesia did not affect the plasma level of luteinizing hormone (LH) in male subjects throughout surgery, but a significant decrease was detected in female patients on the first postoperative day. The plasma concentrations of testosterone decreased during anaesthesia alone and surgery, and a further decrease was noted on the first postoperative day.
45例患者接受了安氟醚麻醉及手术。仅麻醉时，促肾上腺皮质激素（ACTH）、皮质醇或抗利尿激素（ADH）的血浆浓度变化不大，但手术期间这些激素浓度显著升高。仅麻醉期间醛固酮的血浆水平就升高，手术期间进一步升高。安氟醚麻醉和手术均未显著影响肾素活性和甲状腺素的血浆浓度。仅麻醉期间就检测到血浆三碘甲状腺原氨酸水平显著下降，手术期间及术后进一步下降。在整个手术过程中，安氟醚麻醉未影响男性受试者促黄体生成素（LH）的血浆水平，但在女性患者术后第一天检测到显著下降。睾酮的血浆浓度在仅麻醉和手术期间下降，术后第一天进一步下降。
