Antsaklis A, Daskalakis G, Michalas S, Aravantinos D
First Department of Obstetrics and Gynecology, Athens University Medical School, Alexandra Maternity Hospital, Greece.
Fetal Diagn Ther. 1997 Mar-Apr;12(2):89-92. doi: 10.1159/000264438.
This study was undertaken to test the effects of erythromycin as an adjunct to tocolysis for preterm labor in women with vaginal cultures positive for Ureaplasma urealyticum. The study group consisted of 18 women in active preterm labor with pregnancies between 26 and 34 weeks of gestation and intact membranes who received 500 mg erythromycin orally every 8 h for 10 days. Seventeen women with similar characteristics served as controls and received no antibiotics. In all women contractions were suppressed with ritodrine. Erythromycin treatment resulted in a statistically significant greater mean delay of delivery (36.4 days) than among the control group (23.1 days). Higher proportion of term pregnancies (7 versus 3 pregnancies), higher mean birth weight (2,745 versus 2,474 g), lower neonatal morbidity (22.2 versus 42.2%) and shorter mean neonatal hospitalization time (9.6 versus 12.1 days) were observed, although these differences were not statistically significant. Adjunctive erythromycin treatment given to women treated for preterm labor with intact membranes and positive vaginal cultures for U. urealyticum appears to prolong gestation and to improve perinatal outcome.
本研究旨在测试红霉素作为溶酶体辅助药物对解脲脲原体阴道培养阳性的早产妇女的影响。研究组由18名妊娠26至34周、胎膜完整且处于早产活跃期的妇女组成，她们每8小时口服500毫克红霉素，共10天。17名具有相似特征的妇女作为对照组，未接受抗生素治疗。所有妇女均使用利托君抑制宫缩。与对照组（23.1天）相比，红霉素治疗使分娩平均延迟时间在统计学上显著延长（36.4天）。观察到足月妊娠比例更高（7例对3例）、平均出生体重更高（2745克对2474克）、新生儿发病率更低（22.2%对42.2%）以及新生儿平均住院时间更短（9.6天对12.1天），尽管这些差异无统计学意义。对于胎膜完整且解脲脲原体阴道培养阳性的早产妇女，辅助使用红霉素治疗似乎可延长妊娠期并改善围产期结局。
