Dykes P J, Marks R
Br J Dermatol. 1977 Sep;97(3):327-34. doi: 10.1111/j.1365-2133.1977.tb15191.x.
Four patients with acquired ichthyosis are described and the results of histological, histometric, autoradiographic and enzyme histochemical studies reported. Three of the patients were found to have in addition the following underlying diseases--malnutrition, reticulum cell sarcoma and panhypopituitarism. The fourth patient did not have any systemic disorder and the provoking cause of his ichthyotic condition remains obscure. Clinically these patients demonstrated the skin changes of autosomal dominant ichthyosis although their condition tended to fluctuate in severity. The various studies performed indicated that the histological and metabolic changes tended to reflect the clinical state of the patients and that these parameters did not differ significantly from those observed in atuosomal dominant ichthyosis.
本文描述了4例获得性鱼鳞病患者，并报告了组织学、组织计量学、放射自显影和酶组织化学研究结果。其中3例患者还伴有以下基础疾病——营养不良、网状细胞肉瘤和全垂体功能减退。第4例患者没有任何全身性疾病，其鱼鳞病的诱发原因仍不清楚。临床上，这些患者表现出常染色体显性鱼鳞病的皮肤改变，尽管其病情严重程度有波动。所进行的各项研究表明，组织学和代谢变化往往反映了患者的临床状态，且这些参数与常染色体显性鱼鳞病患者所观察到的参数无显著差异。
