Tarkkanen A, Laatikainen L
Br J Ophthalmol. 1977 Sep;61(9):608-16. doi: 10.1136/bjo.61.9.608.
Five patients who had had neonatal herpes simplex virus infection were re-examined at ages that varied from 6 to 9 years. In all of them the diagnosis had been supported by virus isolation and antibody titration, and herpes virus type 2, the genital strain, had been the causative agent. Only 1 of the patients was mentally retarded. Three of the patients had manifest squint, and only 1 patient had normal visual acuity in both eyes. The fundus changes varied from atrophy of the retinal pigment epithelium in 3 patients to atrophy of the optic disc in 2 eyes and extreme tortuosity of the retinal arterioles and veins in 1 patient. One patient developed bilateral retinitis with exudation into the vitreous at the age of 5 years. Fluorescein angiography of this patient showed peripheral vascular closure and preretinal neovascularisation, with leakage in both eyes. This may have been due to chronic retinal vasculitis; haemorrhagic infarction may have induced the damage to retinal tissues. Laser photocogulation resulted in slight improvement of the visual acuity, clearing of the vitreous, and decrease of the fluorescein leakage.
5名曾患新生儿单纯疱疹病毒感染的患者在6至9岁的不同年龄段接受了复查。所有患者的诊断均通过病毒分离和抗体滴定得到证实，致病原因为2型疱疹病毒（生殖器毒株）。只有1名患者智力发育迟缓。3名患者有明显斜视，只有1名患者双眼视力正常。眼底改变各异，3名患者为视网膜色素上皮萎缩，2只眼为视盘萎缩，1名患者视网膜动静脉极度迂曲。1名患者在5岁时发生双侧视网膜炎并伴有玻璃体渗出。该患者的荧光素血管造影显示周边血管闭塞和视网膜前新生血管形成，双眼均有渗漏。这可能是由于慢性视网膜血管炎所致；出血性梗死可能导致了视网膜组织的损伤。激光光凝使视力略有改善，玻璃体混浊减轻，荧光素渗漏减少。
