el Azazi M, Malm G, Forsgren M
Department of Ophthalmology, Huddinge University Hospital, Sweden.
Am J Ophthalmol. 1990 Jan 15;109(1):1-7. doi: 10.1016/s0002-9394(14)75569-2.
We examined 32 children one to 15 years after virologically verified neonatal herpes simplex virus infection. Sixteen of 17 (94%) neurologically impaired children had ocular abnormalities compared to three of 15 (20%) neurologically healthy children. Disturbed oculomotor control occurred in 14 children (44%), most of whom were among those with severe handicap. Ocular morbidity was present in 13 (40%) of 32 children: one had cataracts, two had corneal scars, seven had optic atrophy, and nine had chorioretinal scars. The clinically silent chorioretinal lesions were manifest as coarse hyperpigmented areas between the equator and ora serrata. One child had suffered from acute fulminant retinitis. Twelve of 13 (93%) severely handicapped children had impaired vision, mainly because of cortical blindness. Less affected children had normal vision unless corneal scars were present. Long-term observation of patients with neonatal herpes infections is essential because ocular manifestations are not rare, and recurrences may be more common than previously reported.
我们对32名经病毒学证实患有新生儿单纯疱疹病毒感染的儿童进行了1至15年的随访检查。17名神经功能受损儿童中有16名（94%）存在眼部异常，而15名神经功能正常的儿童中只有3名（20%）有眼部异常。14名儿童（44%）出现眼动控制障碍，其中大多数属于重度残疾儿童。32名儿童中有13名（40%）存在眼部疾病：1名患有白内障，2名有角膜瘢痕，7名有视神经萎缩，9名有脉络膜视网膜瘢痕。临床上无症状的脉络膜视网膜病变表现为赤道与锯齿缘之间的粗大色素沉着区域。1名儿童曾患急性暴发性视网膜炎。13名重度残疾儿童中有12名（93%）视力受损，主要原因是皮质盲。除非存在角膜瘢痕，否则受影响较小的儿童视力正常。对新生儿疱疹感染患者进行长期观察至关重要，因为眼部表现并不罕见，而且复发可能比之前报道的更为常见。
