Pettay O, Leinikki P, Donner M, Lapinleimu K
Arch Dis Child. 1972 Feb;47(251):97-103. doi: 10.1136/adc.47.251.97.
Fourteen cases of neonatal herpes simplex virus infection in 10 boys and 4 girls are described. The disease was disseminated in 9 cases. In 5 cases skin symptoms predominated, and 1 had only central nervous system symptoms. Two had a vesicular eruption when born. Six of the children with disseminated disease died. EEG recordings were made on 7 patients: 5 had clinical symptoms compatible with encephalitis, and in these the EEG showed periodic complexes, consisting of triangular or sharp waves, a pattern described in adult cases of herpetic encephalitis. The diagnosis was made by virus isolation and antibody titration. Herpes virus type 2 was the causative agent in all 8 cases where the type was determined. In 5 patients herpes virus antigen was demonstrated using immunofluorescence either in vesicles or throat swabs, in the early phase of the disease. Two children with generalized disease were treated with intravenous iododeoxyuridine (IDU). The first died, but the other, treated early in his disease, recovered completely. The clinical picture, complemented by the immunofluorescent technique for virus detection and repeated EEG recordings, should lead to the early diagnosis of herpetic encephalitis in the newborn, and warrant the use of systemic IDU treatment.
本文描述了14例新生儿单纯疱疹病毒感染病例，其中男10例，女4例。9例为播散性疾病。5例以皮肤症状为主，1例仅有中枢神经系统症状。2例出生时即有疱疹性皮疹。6例播散性疾病患儿死亡。对7例患者进行了脑电图记录：5例有与脑炎相符的临床症状，脑电图显示有周期性复合波，由三角形或尖波组成，这是成人疱疹性脑炎病例中描述的一种模式。诊断通过病毒分离和抗体滴定进行。在确定病毒类型的所有8例病例中，2型疱疹病毒是病原体。在疾病早期，5例患者在水疱或咽拭子中通过免疫荧光法检测到疱疹病毒抗原。2例全身性疾病患儿接受了静脉注射碘脱氧尿苷（IDU）治疗。第一例死亡，但另一例在疾病早期接受治疗，完全康复。结合病毒检测的免疫荧光技术和重复的脑电图记录，临床表现应能早期诊断新生儿疱疹性脑炎，并保证使用全身性IDU治疗。
