Guillon M, Styles E, Guillon J P, Maïssa C
Laboratoire de Biochimie des Transports Cellulaires, Centre Scientifique d'Orsay, Universite de Paris-Sud,
Optom Vis Sci. 1997 May;74(5):273-9. doi: 10.1097/00006324-199705000-00022.
The aims of the current investigation were to: (1) characterize (structure, volume, and stability) the preocular tear film of contact lens wearers and nonwearers and (2) test for any difference between contact lens wearers and nonwearers and between symptomatic and asymptomatic subjects. The tear film structure and stability were tested using the Tearscope in conjunction with the biomicroscope observation system. The tear prism height, which is indicative of the tear volume, was measured with the slitlamp. The study was carried out on 239 subjects (478 eyes) who attended our clinic for contact lens fitting. Of these, 184 were habitual daily soft contact lens wearers who had not been wearing contact lenses for at least 24 h; the other 55 were noncontact lens wearers. The results obtained showed that: (1) the stability of the tear film was correlated for two eyes of the same subject; (2) the structure, volume, and stability of the preocular tear film were similar for both groups; (3) no difference in tear film stability was found between asymptomatic and symptomatic contact lens wearers, but a significant difference was found between asymptomatic and symptomatic noncontact tact wearers; and (4) the stability of the tear film was influenced by the nature of the lipid layer present at the surface of the aqueous layer; the greatest stability was achieved when the lipid layer was thick and homogeneous (amorphous pattern).
（1）描述（结构、体积和稳定性）隐形眼镜佩戴者和非佩戴者的眼前泪膜；（2）测试隐形眼镜佩戴者和非佩戴者之间以及有症状和无症状受试者之间是否存在差异。使用泪液镜结合生物显微镜观察系统测试泪膜结构和稳定性。用裂隙灯测量指示泪液体积的泪棱镜高度。该研究对239名到我们诊所进行隐形眼镜验配的受试者（478只眼）进行。其中，184名是日常习惯性佩戴软性隐形眼镜且至少24小时未佩戴隐形眼镜的人；另外55名是非隐形眼镜佩戴者。获得的结果表明：（1）同一受试者的两只眼睛的泪膜稳定性具有相关性；（2）两组的眼前泪膜结构、体积和稳定性相似；（3）无症状和有症状的隐形眼镜佩戴者之间未发现泪膜稳定性差异，但无症状和有症状的非隐形眼镜佩戴者之间发现了显著差异；（4）泪膜稳定性受水层表面脂质层性质的影响；当脂质层厚且均匀（无定形模式）时，稳定性最佳。
