Serkedjieva J, Ivanova E
Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Acta Virol. 1997 Apr;41(2):65-70.
The protective effect of an immunostimulatory bacterial preparation, cytoplasmic membranes of Escherichia coli WF stable protoplast type L-forms (CM) alone and in combination with the selective antiviral drug rimantadine was evaluated in experimental influenza A/Aichi/2/68 (H3N2) virus infection in mice. In sublethal infection, CM administered intraperitoneally (i.p.) 7 days before virus exposure in a single dose of 25 mg/kg did not reduce significantly the virus lung titers. In lethal infection, CM applied in the same way weakly reduced the mortality rate. The combined application of CM with rimantadine resulted in synergistically increased protection, determined on the basis of virus lung titers, lung consolidation, mortality rates, protective indices, and survival times.
在小鼠感染甲型流感病毒A/Aichi/2/68（H3N2）的实验中，评估了免疫刺激细菌制剂——大肠杆菌WF稳定原生质体L型细胞质膜（CM）单独以及与选择性抗病毒药物金刚烷胺联合使用时的保护作用。在亚致死性感染中，于病毒暴露前7天腹腔注射（i.p.）单剂量25mg/kg的CM，并未显著降低病毒在肺中的滴度。在致死性感染中，以同样方式应用的CM轻微降低了死亡率。基于病毒肺滴度、肺实变、死亡率、保护指数和存活时间测定，CM与金刚烷胺联合应用产生了协同增强的保护作用。
