Serkedjieva J, Roeva I, Angelova M, Dolashka P, Voelter W G
Institute of Microbiology, Bulgarian Academy of Sciences, 26 Acad. G. Bonchev Str., 1113 Sofia, Bulgaria.
Acta Virol. 2003;47(1):53-6.
The combined protective effect of a novel naturally glycosylated Cu/Zn-containing superoxide dismutase, produced by the fungus Humicula lutea (HL-SOD) strain 103, and the selective anti-influenza drug rimantadine hydrochloride (Rim) was evaluated in experimental virus infection in mice, induced with influenza virus A/Aichi/2/68 (H3N2). A combined application of HL-SOD and Rim in doses, which by themselves did not protect significantly mice against the infection, resulted in a synergistically increased protection, determined on the basis of protective indices. Lung virus titers, lung weights and consolidation and mortality rates were all decreased significantly, while survival times were prolonged.
评估了由真菌黄腐菌（HL-SOD）菌株103产生的新型天然糖基化含铜/锌超氧化物歧化酶与选择性抗流感药物盐酸金刚烷胺（Rim）的联合保护作用，该联合作用是在A/爱知/2/68（H3N2）甲型流感病毒诱导的小鼠实验性病毒感染中进行评估的。单独使用时对小鼠感染无明显保护作用的HL-SOD和Rim剂量联合应用，基于保护指数测定显示具有协同增强的保护作用。肺病毒滴度、肺重量、实变和死亡率均显著降低，同时生存时间延长。
