Pancheva S, Gegova G, Maksimova V, Manolova N
Acta Microbiol Bulg. 1990;26:26-9.
The antiviral effect of rimantadine and isoprinosine applied in combination against fowl plague virus (FPV) in cell cultures of chick embryo fibroblasts and in experimental influenza infection in mice has been studied. Isoprinosine does not inhibit the reproduction of FPV when given alone and does not increase the antiviral activity of rimantadine. After oral application of both substances according to an appropriate scheme in mice infected with influenza virus A/Aichi (N3N2), an increase in the antiviral effect with an index of protection by 12% higher than the theoretically calculated one for additive effect was established. The results suggest that the combined effect is synergic.
已经研究了金刚乙胺和异丙肌苷联合应用对鸡胚成纤维细胞培养物中的鸡瘟病毒（FPV）以及对小鼠实验性流感感染的抗病毒作用。单独给予异丙肌苷时不抑制FPV的繁殖，也不增强金刚乙胺的抗病毒活性。按照适当方案对感染甲型/爱知（N3N2）流感病毒的小鼠口服给予这两种物质后，确定抗病毒效果有所增强，保护指数比理论计算的相加效应高12%。结果表明联合效应具有协同性。
