Døssing M, Petersen K T, Vyberg M, Olsen J H
Department of Medicine P, Bispebjerg Hospital, Copenhagen NV, Denmark.
Am J Ind Med. 1997 Sep;32(3):248-54. doi: 10.1002/(sici)1097-0274(199709)32:3<248::aid-ajim10>3.0.co;2-v.
To test the hypothesis that occupational exposure to chemical agents-particularly organic solvents in certain industries-may cause primary liver cancer (PLC), a nested case-control study of PLC cases from the Danish Cancer Registry and an age- and sex-stratified random sample of controls from the Central Population Register in Denmark were linked with files of a national supplementary pension fund. Employment histories since April 1964 were obtained for 973 cases histologically classified as hepatocellular carcinoma, cholangiocarcinoma, or combined hepatocellular and cholangiocarcinoma and 15,348 controls. Men from 35 different industrial branches, women from 7 branches, and both men and women from 3 branches had an excess risk of PLC, with an odds ratio of (OR) > 1.0; 29 branches had an OR of liver cancer in excess of 3.0. Women from bookprinting and offset printing industries had an OR above 10. Only male farmers had an OR below unity (0.41). Employees from breweries, restaurants, hotels, motels, and distilleries had an increased OR of both PLC and esophageal cancer.
为检验职业接触化学物质（尤其是某些行业中的有机溶剂）可能导致原发性肝癌（PLC）这一假设，丹麦癌症登记处的PLC病例巢式病例对照研究以及丹麦中央人口登记处按年龄和性别分层的对照随机样本与一个国家补充养老基金的档案进行了关联。获取了973例经组织学分类为肝细胞癌、胆管癌或肝细胞与胆管癌混合型病例以及15348例对照自1964年4月以来的就业史。来自35个不同工业分支的男性、7个分支的女性以及3个分支的男性和女性患PLC的风险过高，比值比（OR）>1.0；29个分支的肝癌OR超过3.0。来自书籍印刷和胶印行业的女性OR高于10。只有男性农民的OR低于1（0.41）。来自啤酒厂、餐馆、酒店、汽车旅馆和酿酒厂的员工患PLC和食管癌的OR均增加。
