Miller K E, Samuels D C
Department of Anatomy and Cell Biology, Emory University, Atlanta, GA 30322, USA.
J Theor Biol. 1997 Jun 7;186(3):373-9. doi: 10.1006/jtbi.1996.0355.
We present a model that predicts the maximum axonal length from the apparent velocity of slow axonal transport and cytoskeletal protein half-life. The model assumes that in mature axons the apparent velocity of slow transport varies with position, but that the density of cytoskeletal proteins and protein degradation are uniform. The model predicts that the apparent transport velocity of cytoskeletal proteins if highest near the cell body and decreases linearly along the axon, and that when axons branch the apparent velocity of transport decreases across the branch point. The predictions of this model are shown to be consistent with experiments. These results explain the variation in these fundamental metabolic parameters in different axons and species.
我们提出了一个模型，该模型可根据慢轴突运输的表观速度和细胞骨架蛋白半衰期预测最大轴突长度。该模型假设，在成熟轴突中，慢运输的表观速度随位置而变化，但细胞骨架蛋白的密度和蛋白质降解是均匀的。该模型预测，细胞骨架蛋白的表观运输速度在靠近细胞体处最高，并沿轴突呈线性下降，并且当轴突分支时，运输的表观速度在分支点处会降低。该模型的预测结果与实验结果一致。这些结果解释了不同轴突和物种中这些基本代谢参数的变化。
