Park J B, Kenner G H, Brown S D, Scott J K
Biomater Med Devices Artif Organs. 1977;5(3):267-76. doi: 10.3109/10731197709118677.
Since barium titanate (BaTi03) can be made piezoelectric, it may be used to substitute hard tissues directly. As a first step in testing this concept, a series of in vivo and in vitro aging and biocompatibility studies were performed. The mean compressive strength of samples implanted subcutaneously in the backs of rabbits decreased to 138 MPa after 20 weeks from a control value of 281 MPa. Similar, though less drastic losses of strength were seen when specimens were aged in distilled water (182 MPa at 28 weeks) and Ringer's solution (159 MPa at 28 weeks). The most rapid decrease of strength in all cases was seen prior to 4 weeks. Thereafter, the decrease was much slower. Histological evaluation of the tissue surrounding the implant revealed a thin fibrous capsule and no evidence of tissue inflammation.
