Park J B, Kelly B J, Kenner G H, von Recum A F, Grether M F, Coffeen W W
J Biomed Mater Res. 1981 Jan;15(1):103-10. doi: 10.1002/jbm.820150114.
The suitability of barium titanate (BaTiO3) ceramic for direct substitution of hard tissues was evaluated using both electrically stimulated (piezoelectric) and inactive (nonpolarized) test implants. Textured cylindrical specimens, half of them made piezoelectric by polarization in a high electric field, were implanted into the cortex of the midshaft region of the femora of dogs for various periods of time. Interfacial healing and bio-compatibility of the implant material were studied using mechanical, microradiographical, and histological techniques. Our results indicate that barium titanate ceramic shows a very high degree of biocompatibility as evidenced by the absence of inflammatory or foreign body reactions at the implant-tissue interface. Furthermore, the material and its surface porosity allowed a high degree of bone ingrowth as evidenced by microradiography and a high degree of interfacial tensile strength. No difference was found between the piezoelectric and the electrically neutral implant-tissue interfaces. Possible reasons for this are discussed. The excellent mechanical properties of barium titanate, its superior biocompatibility, and the ability of bone to form a strong mechanical interfacial bond with it, makes this material a new candidate for further tests for hard tissue replacement.
使用电刺激（压电）和非活性（非极化）测试植入物评估钛酸钡（BaTiO₃）陶瓷直接替代硬组织的适用性。将有纹理的圆柱形标本植入狗股骨中轴区域的皮质中不同时间段，其中一半通过在高电场中极化制成压电体。使用机械、显微放射学和组织学技术研究植入材料的界面愈合和生物相容性。我们的结果表明，钛酸钡陶瓷显示出非常高的生物相容性，植入物 - 组织界面没有炎症或异物反应证明了这一点。此外，材料及其表面孔隙率允许高度的骨向内生长，显微放射学证明了这一点，并且界面拉伸强度很高。压电和电中性植入物 - 组织界面之间没有发现差异。讨论了可能的原因。钛酸钡优异的机械性能、其卓越的生物相容性以及骨与它形成强机械界面结合的能力，使这种材料成为硬组织替代进一步测试的新候选材料。
