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Separation of enantiomers of drugs by capillary electrophoresis. Part 4: hydroxypropyl-gamma-cyclodextrin as chiral solvating agent.

作者信息

Koppenhoefer B, Epperlein U, Xiaofeng Z, Bingcheng L

机构信息

Institute for Organic Chemistry, University of Tübingen, Germany.

出版信息

Electrophoresis. 1997 Jun;18(6):924-30. doi: 10.1002/elps.1150180612.

DOI:10.1002/elps.1150180612
PMID:9221879
Abstract

In an extended chiral drug screening program, enantioseparation of 86 racemic drugs was tested with hydroxypropyl-gamma-cyclodextrin as chiral solvating agent (CSA). A total of 30 drugs out of 86 could be resolved in this straightforward approach. The number of experiments performed under identical conditions allows a statistical treatment of the data. The enantioseparation of the analytes is correlated with their interaction strength with the CSA. Hence, the concentration of the CSA is a crucial parameter for optimization of the enantioseparation, as shown by a subset of 23 examples.

摘要

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