Hayashi K, Hayashi T, Otsuka H, Takeda Y
Department of Virology, Toyama Medical and Pharmaceutical University, Sugitani, Japan.
J Antimicrob Chemother. 1997 Jun;39(6):821-4. doi: 10.1093/jac/39.6.821.
A naturally occurring flavone, 5,6,7-trimethoxyflavone (TMF), isolated from the plant Callicarpa japonica, was subjected to antiviral assays. The compound exhibited relatively high inhibitory effects on herpes simplex virus type 1 (HSV-1), human cytomegalovirus and poliovirus. The anti-HSV-1 action was not due to the inhibition of virus adsorption, entry and viral protein synthesis, but might involve, at least in part, a virucidal activity, which results in a suppression of viral binding to host cells at an early replication stage. TMF and acylovir were synergic in their anti-HSV activities at levels below the 50% inhibitory concentrations for antiviral activity.
从植物紫珠中分离出的一种天然黄酮类化合物5,6,7-三甲氧基黄酮（TMF）进行了抗病毒试验。该化合物对1型单纯疱疹病毒（HSV-1）、人巨细胞病毒和脊髓灰质炎病毒表现出较高的抑制作用。抗HSV-1的作用不是由于抑制病毒吸附、进入和病毒蛋白合成，而是可能至少部分涉及杀病毒活性，这导致在早期复制阶段抑制病毒与宿主细胞的结合。在低于抗病毒活性50%抑制浓度的水平下，TMF和阿昔洛韦在抗HSV活性方面具有协同作用。
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