Xu Lin, Zhong Xuan-Lei, Xi Zhi-Chao, Li Yang, Xu Hong-Xi
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, China.
Front Microbiol. 2022 Oct 10;13:1025605. doi: 10.3389/fmicb.2022.1025605. eCollection 2022.
Herpes simplex virus (HSV), an alphaherpesvirus, is highly prevalent in the human population and is known to cause oral and genital herpes and various complications. Represented by acyclovir (ACV), nucleoside analogs have been the main clinical treatment against HSV infection thus far. However, due to prolonged and excessive use, HSV has developed ACV-resistant strains. Therefore, effective treatment against ACV-resistant HSV strains is urgently needed. In this review, we summarized the plant extracts and natural compounds that inhibited ACV-resistant HSV infection and their mechanism of action.
单纯疱疹病毒（HSV）是一种α疱疹病毒，在人群中高度流行，已知可引起口腔和生殖器疱疹以及各种并发症。核苷类似物以阿昔洛韦（ACV）为代表，是迄今为止治疗HSV感染的主要临床药物。然而，由于长期过量使用，HSV已产生了对ACV耐药的毒株。因此，迫切需要针对耐ACV的HSV毒株的有效治疗方法。在这篇综述中，我们总结了抑制耐ACV的HSV感染的植物提取物和天然化合物及其作用机制。
