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两种抗雌激素药物枸橼酸氯米芬和他莫昔芬对宫颈黏液及精子-宫颈黏液相互作用的影响。

Effect of two anti-estrogens, clomiphene citrate and tamoxifen, on cervical mucus and sperm-cervical mucus interaction.

作者信息

Annapurna V, Dhaliwal L K, Gopalan S

机构信息

Department of Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

出版信息

Int J Fertil Womens Med. 1997 May-Jun;42(3):215-8.

PMID:9222807
Abstract

OBJECTIVE

To compare the effect of two ovulation-inducing agents, clomiphene citrate and tamoxifen, on cervical mucus and sperm-cervical mucus interaction.

SUBJECTS AND SETTING

Forty couples with unexplained infertility attending infertility clinic.

METHODS

Cervical mucus scoring and postcoital test done using the Moghissi system in a spontaneous cycle (control cycle) and with clomiphene citrate or tamoxifen (study cycles).

RESULTS

Clomiphene citrate significantly decreased cervical mucus production, whereas tamoxifen significantly improved the total score.

CONCLUSION

Tamoxifen is a better drug than clomiphene for ovulation induction in women with poor cervical mucus quality.

摘要

目的

比较两种促排卵药物枸橼酸氯米芬和他莫昔芬对宫颈黏液及精子-宫颈黏液相互作用的影响。

研究对象与地点

40对不明原因不孕的夫妇,就诊于不孕不育门诊。

方法

采用莫吉西系统在自然周期(对照周期)以及使用枸橼酸氯米芬或他莫昔芬的周期(研究周期)进行宫颈黏液评分和性交后试验。

结果

枸橼酸氯米芬显著减少宫颈黏液分泌,而他莫昔芬显著提高总分。

结论

对于宫颈黏液质量差的女性,他莫昔芬在促排卵方面是比枸橼酸氯米芬更好的药物。

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1
Effect of two anti-estrogens, clomiphene citrate and tamoxifen, on cervical mucus and sperm-cervical mucus interaction.两种抗雌激素药物枸橼酸氯米芬和他莫昔芬对宫颈黏液及精子-宫颈黏液相互作用的影响。
Int J Fertil Womens Med. 1997 May-Jun;42(3):215-8.
2
The effect of clomiphene citrate and tamoxifen on the cervical mucus.
Acta Obstet Gynecol Scand. 1988;67(4):311-4.
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Cervical mucus score and in vitro sperm mucus interaction in spontaneous and clomiphene citrate cycles.自然周期与枸橼酸氯米芬周期中的宫颈黏液评分及体外精子与黏液的相互作用
Fertil Steril. 1991 Sep;56(3):465-8. doi: 10.1016/s0015-0282(16)54541-5.
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[Decreased quality of cervix mucus under the influence of clomiphene: a meta-analysis].[克罗米芬影响下宫颈黏液质量下降:一项荟萃分析]
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The effect of three anti-oestrogen drugs on cervical mucus quality and in-vitro sperm-cervical mucus interaction in ovulatory women.三种抗雌激素药物对排卵期女性宫颈黏液质量及体外精子 - 宫颈黏液相互作用的影响。
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Comparison of tamoxifen and clomiphene citrate for ovulation induction: a meta-analysis.他莫昔芬与枸橼酸氯米芬用于诱导排卵的比较:一项荟萃分析。
Hum Reprod. 2005 Jun;20(6):1511-5. doi: 10.1093/humrep/deh840. Epub 2005 Apr 21.
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Effects of clomiphene citrate on cervical mucus: analysis of some influencing factors.
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Comparison between tamoxifen and clomiphene for induction of ovulation.他莫昔芬与克罗米芬诱导排卵的比较。
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Changes in cervical mucus that prevent penetration by spermatozoa.宫颈黏液的变化可阻止精子穿透。
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[Biophysical characteristics of cervical mucus after stimulation of ovulation by clomiphene citrate and HMG].
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