两种抗雌激素药物枸橼酸氯米芬和他莫昔芬对宫颈黏液及精子-宫颈黏液相互作用的影响。
Effect of two anti-estrogens, clomiphene citrate and tamoxifen, on cervical mucus and sperm-cervical mucus interaction.
作者信息
Annapurna V, Dhaliwal L K, Gopalan S
机构信息
Department of Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
出版信息
Int J Fertil Womens Med. 1997 May-Jun;42(3):215-8.
OBJECTIVE
To compare the effect of two ovulation-inducing agents, clomiphene citrate and tamoxifen, on cervical mucus and sperm-cervical mucus interaction.
SUBJECTS AND SETTING
Forty couples with unexplained infertility attending infertility clinic.
METHODS
Cervical mucus scoring and postcoital test done using the Moghissi system in a spontaneous cycle (control cycle) and with clomiphene citrate or tamoxifen (study cycles).
RESULTS
Clomiphene citrate significantly decreased cervical mucus production, whereas tamoxifen significantly improved the total score.
CONCLUSION
Tamoxifen is a better drug than clomiphene for ovulation induction in women with poor cervical mucus quality.
目的
比较两种促排卵药物枸橼酸氯米芬和他莫昔芬对宫颈黏液及精子-宫颈黏液相互作用的影响。
研究对象与地点
40对不明原因不孕的夫妇，就诊于不孕不育门诊。
方法
采用莫吉西系统在自然周期（对照周期）以及使用枸橼酸氯米芬或他莫昔芬的周期（研究周期）进行宫颈黏液评分和性交后试验。
结果
枸橼酸氯米芬显著减少宫颈黏液分泌，而他莫昔芬显著提高总分。
结论
对于宫颈黏液质量差的女性，他莫昔芬在促排卵方面是比枸橼酸氯米芬更好的药物。
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