Effect of two anti-estrogens, clomiphene citrate and tamoxifen, on cervical mucus and sperm-cervical mucus interaction.

OBJECTIVE

To compare the effect of two ovulation-inducing agents, clomiphene citrate and tamoxifen, on cervical mucus and sperm-cervical mucus interaction.

SUBJECTS AND SETTING

Forty couples with unexplained infertility attending infertility clinic.

METHODS

Cervical mucus scoring and postcoital test done using the Moghissi system in a spontaneous cycle (control cycle) and with clomiphene citrate or tamoxifen (study cycles).

RESULTS

Clomiphene citrate significantly decreased cervical mucus production, whereas tamoxifen significantly improved the total score.

CONCLUSION

Tamoxifen is a better drug than clomiphene for ovulation induction in women with poor cervical mucus quality.