Acharya U, Irvine D S, Hamilton M P, Templeton A A
Department of Obstetrics and Gynaecology, University of Aberdeen, Aberdeen Maternity Hospital, UK.
Hum Reprod. 1993 Mar;8(3):437-41. doi: 10.1093/oxfordjournals.humrep.a138067.
The anti-oestrogens, clomiphene citrate, tamoxifen and cyclofenil are commonly used in the treatment of female infertility. Their role in the management of anovulation is well established but there is continuing controversy about their relevance to other areas of management. We have studied the effects of each of these drugs on cervical mucus and sperm-cervical mucus interaction among 23 patients with unexplained infertility. Each patient received all three drugs in an alternative month treatment regime and in addition acted as her own control. The starting point in each patient was randomized. Luteinizing hormone (LH) and oestradiol were measured daily from day 10, and follicle scanning was also undertaken. Cervical mucus quality and sperm-cervical mucus interaction were studied on the day of onset of the LH surge. The use of clomiphene and tamoxifen resulted in a significant reduction in cervical mucus score and sperm-cervical mucus interaction as judged by the distance travelled by the vanguard spermatozoa. Cyclofenil had no effect on these parameters.
抗雌激素药物克罗米芬柠檬酸盐、他莫昔芬和环芬尼常用于治疗女性不孕症。它们在治疗无排卵方面的作用已得到充分证实，但在其他治疗领域的相关性仍存在争议。我们研究了这三种药物对23例不明原因不孕症患者宫颈黏液及精子与宫颈黏液相互作用的影响。每位患者采用交替月治疗方案接受这三种药物治疗，此外，患者自身作为对照。每位患者的起始点是随机确定的。从第10天开始每天测量促黄体生成素（LH）和雌二醇，同时进行卵泡扫描。在LH峰出现当天研究宫颈黏液质量和精子与宫颈黏液的相互作用。根据先锋精子游动的距离判断，克罗米芬和他莫昔芬的使用导致宫颈黏液评分和精子与宫颈黏液相互作用显著降低。环芬尼对这些参数没有影响。
