Hao S, Ogawa H
Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical College, Japan.
Life Sci. 1998;63(11):PL 167-73. doi: 10.1016/s0024-3205(98)00359-2.
We investigated the effects of spinal nociceptin on formalin-induced spinal sensitization and examined the role of the opioidergic, alpha 2-adrenergic and muscarinic cholinergic receptors in the nociceptin-produced suppression of spinal sensitization. The results demonstrated that spinal nociceptin suppressed the formalin-induced spinal sensitization in a dose-dependent manner (1, 5 and 10 nmol). The inhibitory effect of 10 nmol of nociceptin on spinal sensitization, was readily antagonized by naltrexone, but not by atropine or yohimbine. Each of the antagonists, naltrexone, atropine or yohimbine, alone had no effect on the formalin-induced spinal sensitization. Our results show that spinal nociceptin elicits dose-dependent, naltrexone-reversible suppression of spinal sensitization evoked by injection of formalin.
我们研究了脊髓内孤啡肽对福尔马林诱导的脊髓敏化的影响，并检测了阿片能、α2-肾上腺素能和毒蕈碱胆碱能受体在孤啡肽产生的脊髓敏化抑制作用中的作用。结果表明，脊髓内孤啡肽以剂量依赖方式（1、5和10 nmol）抑制福尔马林诱导的脊髓敏化。10 nmol孤啡肽对脊髓敏化的抑制作用可被纳洛酮迅速拮抗，但不能被阿托品或育亨宾拮抗。拮抗剂纳洛酮、阿托品或育亨宾单独使用时对福尔马林诱导的脊髓敏化均无影响。我们的结果表明，脊髓内孤啡肽对注射福尔马林诱发的脊髓敏化具有剂量依赖的、纳洛酮可逆的抑制作用。
