Fukuda M, Takaki O, Nagata N, Satani M, Kitamura Y
Department of Anesthesiology, Osaka City General Hospital.
Masui. 1997 Jun;46(6):793-7.
We evaluated whether lidocaine tape (3 X 5 cm, contained 18 mg of lidocaine) could reduce pain caused by venous cannulation in children during anesthetic induction. One hundred and thirty-five children scheduled for elective surgery were randomly assigned to three groups according to the application time of the tape (30 min, 60 min and 120 min). Pain assessment was made by using our pain score (0: no response, 1: slight agitation, 2: strong agitation, at the venous cannulation). The effect of pain reduction (pain score 0 and 1) was found in 81 % of all patients. Especially in the group of 120 min, the effect was remarkable. Only 6.7% of all patients had slight adverse effects including skin redness and itching. In another 25 patients (weighing 3.5-30 kg), plasma concentration of lidocaine were measured 120 min after application of a piece of this tape. Arterial blood was sampled at 30 and 120 min after the tape was removed. Plasma lidocaine levels were always below 0.8 mcg.ml-1 In conclusion, the lidocaine tape may be useful and safely applicable for venous cannulation in children.
我们评估了利多卡因贴剂（3×5厘米，含18毫克利多卡因）是否能减轻儿童麻醉诱导期间静脉穿刺引起的疼痛。135名计划进行择期手术的儿童根据贴剂的使用时间（30分钟、60分钟和120分钟）被随机分为三组。通过我们的疼痛评分（0：无反应，1：轻微躁动，2：强烈躁动，在静脉穿刺时）进行疼痛评估。在所有患者中，81%发现有减轻疼痛的效果（疼痛评分为0和1）。特别是在120分钟组，效果显著。所有患者中只有6.7%有轻微不良反应，包括皮肤发红和瘙痒。在另外25名患者（体重3.5 - 30千克）中，在使用一片这种贴剂120分钟后测量利多卡因的血浆浓度。在揭下贴剂后30分钟和120分钟采集动脉血样。血浆利多卡因水平始终低于0.8微克/毫升。总之，利多卡因贴剂可能对儿童静脉穿刺有用且安全适用。
