风湿性多肌痛和巨细胞动脉炎与HLA - B8的关联。
Association of polymyalgia rheumatica and giant-cell arteritis with HLA-B8.
作者信息
Hazleman B, Goldstone A, Voak D
出版信息
Br Med J. 1977 Oct 15;2(6093):989-91. doi: 10.1136/bmj.2.6093.989.
Abstract
Histocompatibility antigens were determined in 30 patients with temporal arteritis, 27 patients with polymyalgia rheumatica, and 216 normal blood donors. HLA-B8 was significantly more common in patients with polymyalgia rheumatica (59%) and temporal arteritis (50%) than in the controls (27%). The findings of HLA-A10 in 26% of the patients with polymyalgia rheumatica compared with only 10% of the controls may be associated with the suggested immunological pathogenesis of the condition.
摘要
对30例颞动脉炎患者、27例风湿性多肌痛患者和216名正常献血者进行了组织相容性抗原检测。风湿性多肌痛患者（59%）和颞动脉炎患者（50%）中HLA - B8的发生率显著高于对照组（27%）。26%的风湿性多肌痛患者中发现有HLA - A10，而对照组中只有10%，这一发现可能与该病推测的免疫发病机制有关。
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