Asakura T, Takano Y, Iki M, Suwa Y, Noguchi S, Kubota Y, Masuda M
Department of Urology, Yokohama City University School of Medicine, Japan.
J Urol. 1997 Aug;158(2):385-8.
We retrospectively reviewed 104 cases of superficial bladder cancer to ascertain whether the Ki-67 labeling index predicts recurrence and progression.
Archival specimens from superficial bladder cancer cases were immunostained with Ki-67.
The recurrence rate was significantly higher in cases with a Ki-67 labeling index of 5.35 or greater than in those with a value less than 5.35 (p < 0.001). The recurrence rate at 2 years was 70% in cases with a Ki-67 labeling index of 5.35 or greater and 22% in those with an index less than 5.35 (p < 0.001). Using multivariate analysis the index predicted recurrence of bladder cancer (p < 0.005). Median Ki-67 labeling index in cases with progression was significantly higher than in those without progression (p < 0.01).
The Ki-67 labeling index is an independent predictive factor for recurrence of superficial bladder cancer.
我们回顾性分析了104例浅表性膀胱癌病例，以确定Ki-67标记指数是否可预测复发和进展情况。
对浅表性膀胱癌病例的存档标本进行Ki-67免疫染色。
Ki-67标记指数为5.35或更高的病例的复发率显著高于该指数低于5.35的病例（p < 0.001）。Ki-67标记指数为5.35或更高的病例2年复发率为70%，而指数低于5.35的病例为22%（p < 0.001）。多因素分析显示该指数可预测膀胱癌复发（p < 0.005）。进展病例的Ki-67标记指数中位数显著高于无进展病例（p < 0.01）。
Ki-67标记指数是浅表性膀胱癌复发的独立预测因素。
