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由伞枝犁头霉引起的创伤后角膜毛霉菌病。

Post-traumatic corneal mucormycosis caused by Absidia corymbifera.

作者信息

Marshall D H, Brownstein S, Jackson W B, Mintsioulis G, Gilberg S M, al-Zeerah B F

机构信息

Department of Ophthalmology, University of Ottawa Eye Institute, Ottawa General Hospital, Ontario, Canada.

出版信息

Ophthalmology. 1997 Jul;104(7):1107-11. doi: 10.1016/s0161-6420(97)30177-8.

Abstract

OBJECTIVE

The purpose of the study was to report a case of mycotic keratitis caused by the organism Absidia corymbifera (class Zygomycetes, order Mucorales, family Mucoraceae).

DESIGN

Case report.

PARTICIPANT

A healthy 37-year-old farmer scratched his left cornea on a galvanized nail while working in his barn. Within 24 hours, an infiltrate in the interior cornea developed that advanced superiorly, reducing the vision to hand motion by the following day. He was treated with topical and systemic antibiotics and antifungal medications, but the infiltrate spread to the adjacent nasal limbus.

INTERVENTION

An 11-mm penetrating keratoplasty was performed with an adjacent nasal 7-mm superficial lamellar sclerectomy.

MAIN OUTCOME MEASURES

Pathologic examination of the keratoplasty specimen.

RESULTS

Corneal cultures grew A. corymbifera. The organisms were identified in tissue sections by light, fluorescent, electron, and immunoelectron microscopy.

CONCLUSIONS

The authors believe that this is the first reported case of keratitis caused by an Absidia species and, as such, represents an unusual form of mucormycosis in an otherwise healthy individual.

摘要

目的

本研究旨在报告一例由伞枝犁头霉(接合菌纲、毛霉目、毛霉科)引起的真菌性角膜炎病例。

设计

病例报告。

参与者

一名37岁健康农民在谷仓干活时,左眼角膜被镀锌钉划伤。24小时内,角膜内出现浸润,并向上发展,到第二天视力降至仅能感知手动。他接受了局部和全身抗生素及抗真菌药物治疗,但浸润蔓延至相邻的鼻侧角膜缘。

干预

实施了11毫米穿透性角膜移植术,并在相邻鼻侧进行了7毫米浅层板层巩膜切除术。

主要观察指标

角膜移植标本的病理检查。

结果

角膜培养物中生长出伞枝犁头霉。通过光学显微镜、荧光显微镜、电子显微镜和免疫电子显微镜在组织切片中鉴定出该微生物。

结论

作者认为这是首例由犁头霉属物种引起的角膜炎报告病例,因此,代表了在其他方面健康个体中一种不寻常的毛霉病形式。

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