Lemke R, Gadient R A, Patterson P H, Bigl V, Schliebs R
Paul Flechsig Institute for Brain Research, University of Leipzig, Medical Faculty, Germany.
Neurosci Lett. 1997 Jun 20;229(1):69-71. doi: 10.1016/s0304-3940(97)00421-7.
We have previously found leukemia inhibitory factor (LIF) mRNA in neurons of the adult rat brain. To identify which neuronal subpopulations are expressing LIF transcripts, non-radioactive in situ hybridization was combined with immunocytochemistry for various neuronal markers. Studying the rat basal forebrain and cerebral cortex, we find LIF mRNA is expressed in both cholinergic and GABAergic neurons. These data suggest a role for LIF in the function of these mature neurons.
我们先前在成年大鼠脑神经元中发现了白血病抑制因子（LIF）mRNA。为了确定哪些神经元亚群表达LIF转录本，将非放射性原位杂交与针对各种神经元标志物的免疫细胞化学相结合。通过研究大鼠基底前脑和大脑皮层，我们发现LIF mRNA在胆碱能神经元和γ-氨基丁酸能神经元中均有表达。这些数据表明LIF在这些成熟神经元的功能中发挥作用。
