Tsujimoto K, Tsuji N, Ozaki K, Minami M, Satoh M, Itoh N
Department of Genetic Biochemistry, Kyoto University Faculty of Pharmaceutical Sciences, Japan.
Neurosci Lett. 1995 Mar 24;188(2):105-8. doi: 10.1016/0304-3940(95)11409-p.
Insulin receptor-related receptor (IRR) is a member of the insulin receptor family. However, its endogenous ligand and the physiological roles of IRR are unknown. To elucidate the physiological roles of IRR in the brain, we examined the expression of its mRNA in the rat brain by in situ hybridization. In contrast to the widespread expression of insulin receptor and insulin-like growth factor-1 receptor mRNAs in the brain, the expression of IRR mRNA was highly restricted to the forebrain cholinergic neurons. All the forebrain cholinergic neurons expressed IRR mRNA. The present findings indicate that IRR has a selective role in the brain for forebrain cholinergic function.
胰岛素受体相关受体（IRR）是胰岛素受体家族的成员。然而，其内源配体以及IRR的生理作用尚不清楚。为了阐明IRR在大脑中的生理作用，我们通过原位杂交检测了其mRNA在大鼠大脑中的表达。与胰岛素受体和胰岛素样生长因子-1受体mRNA在大脑中的广泛表达不同，IRR mRNA的表达高度局限于前脑胆碱能神经元。所有前脑胆碱能神经元均表达IRR mRNA。目前的研究结果表明，IRR在大脑中对前脑胆碱能功能具有选择性作用。
