果蝇微小染色体维持蛋白同源物的克隆及其在胚胎发育过程中的需求分析。
Cloning of Drosophila MCM homologs and analysis of their requirement during embryogenesis.
作者信息
Su T T, Yakubovich N, O'Farrell P H
机构信息
Department of Biochemistry and Biophysics, University of California, San Francisco 94143-0448, USA.
出版信息
Gene. 1997 Jun 19;192(2):283-9. doi: 10.1016/s0378-1119(97)00107-8.
Abstract
MCM (minichromosome maintenance) gene family of Saccharomyces cerevisiae encodes essential DNA replication factors that participate in the initiation of DNA replication. In addition, their localization to the nucleus in a mitosis-dependent manner fueled the hypothesis that MCMs also act to couple DNA replication to mitosis. We report the identification of a Drosophila gene family with extensive sequence identity to the MCM genes. Results from antibody injection experiments suggest that MCMs play an essential role in DNA replication during embryogenesis. Evolutionary conservation of MCM sequences and function in Drosophila could potentially facilitate studies of how initiation of DNA replication is regulated and coupled to mitosis during metazoan development.
摘要
酿酒酵母的MCM（微小染色体维持）基因家族编码参与DNA复制起始的必需DNA复制因子。此外，它们以有丝分裂依赖的方式定位于细胞核，这支持了MCMs也参与将DNA复制与有丝分裂偶联的假说。我们报告了一个与MCM基因具有广泛序列同一性的果蝇基因家族的鉴定。抗体注射实验结果表明，MCMs在胚胎发育过程中的DNA复制中起重要作用。果蝇中MCM序列和功能的进化保守性可能有助于研究后生动物发育过程中DNA复制起始是如何被调控以及与有丝分裂偶联的。
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