Toyoda K, Matsui H, Shoda T, Uneyama C, Takada K, Takahashi M
Division of Pathology, National Institute of Health Sciences, Tokyo, Japan.
Food Chem Toxicol. 1997 Jun;35(6):597-603. doi: 10.1016/s0278-6915(97)00023-9.
The carcinogenic potential of stevioside, a compound that is used as a sweetener for food and drink, was examined in F344 rats of both sexes. Stevioside was added to powdered diet at concentrations of 0 (control), 2.5 and 5%. The doses were selected on the basis of results from a 13-wk subchronic toxicity study and administered to groups of 50 male and 50 female rats ad lib. for 104 wk. All surviving rats were killed at wk 108. Body weight gains were slightly depressed in line with the dose of stevioside, in both sexes, and a significant decrease in the final survival rate was observed for the 5% treated males. Histopathologically, however, there was no significantly altered development of neoplastic or non-neoplastic lesions attributable to the stevioside treatment in any organ or tissue, except for a decreased incidence of mammary adenomas in females and a reduced severity of chronic nephropathy in males. It is concluded that stevioside is not carcinogenic in F344 rats under the experimental conditions described.
甜菊糖苷是一种用于食品和饮料的甜味剂，研究人员在雄性和雌性F344大鼠中检测了其致癌潜力。甜菊糖苷以0（对照）、2.5%和5%的浓度添加到粉状饲料中。这些剂量是根据一项为期13周的亚慢性毒性研究结果选定的，并随意给予每组50只雄性和50只雌性大鼠，持续104周。所有存活的大鼠在第108周时被处死。无论雄性还是雌性，体重增加均随甜菊糖苷剂量的增加而略有下降，且5%剂量组的雄性大鼠最终存活率显著降低。然而，在组织病理学上，除雌性乳腺腺瘤发病率降低和雄性慢性肾病严重程度减轻外，甜菊糖苷处理未导致任何器官或组织的肿瘤性或非肿瘤性病变的发展出现显著改变。结论是，在所述实验条件下，甜菊糖苷对F344大鼠无致癌性。
