Shono N, Kumagai S, Higaki Y, Nishizumi M, Sasaki H
Department of Community Health Science, Saga Medical School, Japan.
J Atheroscler Thromb. 1996;3(1):45-51. doi: 10.5551/jat1994.3.45.
We investigated the relationships of plasma sex hormones (free testosterone; free T, estradiol; E2 dehydroepiandrosterone-sulfate; DHEA-S) and sex hormone-binding globulin (SHBG) levels to lipid and glucose metabolism cross-sectionally in 212 apparently healthy men aged from 18 to 59 years. A multiple linear regression analysis for lipid and glucose parameters with age, body mass index (BMI), percent body fat (%fat), waist to hip ratio (WHR), estimated maximal oxygen uptake (VO2max), alcohol and cigarette consumption, sex hormones, and SHBG, respectively, as independent variables, was performed. DHEA-S was indicated as one of the independent predictors of both high density lipoprotein cholesterol (HDL-C), with a positive relation, and of triglyceride and total cholesterol/HDL-C ratio, with a negative relation, while SHBG was one of the predictors of both HDL-C, with a positive relation, and of fasting insulin, with a negative relation. The E2 level was found to be negatively related to both low density lipoprotein cholesterol and fasting blood glucose. These findings thus suggest that the higher levels of SHBG, DHEA-S and E2 within physiological ranges in healthy men may partially help to maintain a desirable profile of the plasma lipid and glucose metabolism.
我们对212名年龄在18至59岁之间、表面健康的男性进行了横断面研究，以探讨血浆性激素（游离睾酮；游离T、雌二醇；E2、硫酸脱氢表雄酮；DHEA-S）和性激素结合球蛋白（SHBG）水平与脂质及葡萄糖代谢之间的关系。分别以年龄、体重指数（BMI）、体脂百分比（%fat）、腰臀比（WHR）、估计最大摄氧量（VO2max）、酒精和香烟消费量、性激素及SHBG作为自变量，对脂质和葡萄糖参数进行多元线性回归分析。结果表明，DHEA-S是高密度脂蛋白胆固醇（HDL-C）的独立预测因子之一，呈正相关，同时也是甘油三酯和总胆固醇/HDL-C比值的预测因子之一，呈负相关；而SHBG是HDL-C的预测因子之一，呈正相关，也是空腹胰岛素的预测因子之一，呈负相关。发现E2水平与低密度脂蛋白胆固醇和空腹血糖均呈负相关。因此，这些研究结果表明，健康男性在生理范围内较高水平的SHBG、DHEA-S和E2可能部分有助于维持理想的血浆脂质和葡萄糖代谢状况。
