肝素与犬凝血蛋白的相互作用：体内和体外研究
Interaction of heparin with canine coagulation proteins: in vivo and in vitro studies.
作者信息
Gentry P A
出版信息
Can J Comp Med. 1977 Oct;41(4):396-403.
The effects of heparin on the coagulation profile and on specific factor activity in canine plasma have been examined both in vivo and in vitro. The results show that the prolongation of the partial thromboplastin time of plasma produced by heparin is, at least in part, the result of the interaction of heparin with the intrinsic Factors VIII, IX and XI and the inhibition of their procoagulant activity by heparin. A significant correlation was found between the partial thromboplastin time assay and the circulating heparin activity following intravenous administration of heparin to dogs. The results confirm the suitability of the partial thromboplastin time assay for monitoring heparin therapy in the dog.
已在体内和体外研究了肝素对犬血浆凝血谱及特定因子活性的影响。结果表明，肝素引起的血浆部分凝血活酶时间延长，至少部分是肝素与内源性因子VIII、IX和XI相互作用以及肝素抑制它们促凝活性的结果。给犬静脉注射肝素后，部分凝血活酶时间测定与循环肝素活性之间发现有显著相关性。结果证实了部分凝血活酶时间测定适用于监测犬的肝素治疗。
Zotero 插件