Black W D, Gentry P A
Can J Comp Med. 1980 Apr;44(2):141-7.
Sensitized and control calves were challenged with an intravenous dose of 0.2 mL/kg horse serum. Changes in the blood pressure, blood cellular components, plasma kaolin activated p-tosyl-1-arginine methyl ester esterase activity, plasma antithrombin III levels and activated partial thromboplastin time were monitored. Anaphylaxis induced a severe drop in carotid arterial pressure and respiratory distress. There was a decrease in the total white blood cell count from a mean of 10,000 to a low of 1,900 per microL, a decrease in the percentage neutrophils and an increase in the percentage of lymphocytes from 57.4% to 94.8%. A drop was observed in the mean platelet count from 463 x 10(3)/microL. The time required for kaolin to produce maximum p-tosyl-1-arginine methyl ester esterase activation increased from two minutes in the controls to three minutes in calves undergoing anaphylaxis and was observed three to 90 minutes after the administration of horse serum. Antithrombin III levels in the plasma appeared to drop during anaphylaxis but were not significantly depressed (p greater than or equal to 0.5). A statistically significant (p < 0.5) drop in the rate of blood coagulation was observed by the activated partial thromboplastin time assay at 15 to 30 minutes after horse serum injection.
对致敏和对照小牛静脉注射剂量为0.2 mL/kg的马血清进行激发试验。监测血压、血细胞成分、血浆高岭土激活的对甲苯磺酰-1-精氨酸甲酯酯酶活性、血浆抗凝血酶III水平和活化部分凝血活酶时间的变化。过敏反应导致颈动脉血压严重下降和呼吸窘迫。白细胞总数从平均每微升10,000降至最低每微升1,900，中性粒细胞百分比降低，淋巴细胞百分比从57.4%增至94.8%。平均血小板计数从463×10³/微升下降。高岭土产生最大对甲苯磺酰-1-精氨酸甲酯酯酶激活所需时间从对照的两分钟增加到过敏反应小牛的三分钟，在注射马血清后3至90分钟观察到。过敏反应期间血浆抗凝血酶III水平似乎下降，但未显著降低（p大于或等于0.5）。在注射马血清后15至30分钟，通过活化部分凝血活酶时间测定观察到凝血速率有统计学意义的下降（p<0.5）。
