Alemu P, Forsyth G W, Searcy G P
Can J Comp Med. 1977 Oct;41(4):420-7.
Changes in serum enzyme levels, liver histology and liver function tests have been correlated to determine the usefulness of these tests in assessing liver status. The effects of carbon tetrachloride administration on these parameters has been determined in a group of 20 sheep. Normal levels, elevated levels after injury and the effect of elapsed time after injury are reported for serum glutamic dehydrogenase, sorbitol dehydrogenase, glutamic-oxaloacetic transaminase, glutamic-pyruvic transaminase, lactate dehydrogenase, fructose-1-phosphate adlolase, alkaline phosphatase, cholesterol and proteins. Variation in the time of elevation of enzyme activities may be useful in determining the elapsed time between acute injury and serum sampling. In comparison to sheep fed an adequate diet, a diet with a restricted protein intake was associated with increased severity of histological lesions and decreased liver function.
血清酶水平、肝脏组织学和肝功能测试的变化已相互关联，以确定这些测试在评估肝脏状态方面的有用性。在一组20只绵羊中确定了四氯化碳给药对这些参数的影响。报告了血清谷氨酸脱氢酶、山梨醇脱氢酶、谷草转氨酶、谷丙转氨酶、乳酸脱氢酶、果糖-1-磷酸醛缩酶、碱性磷酸酶、胆固醇和蛋白质的正常水平、损伤后的升高水平以及损伤后经过时间的影响。酶活性升高时间的变化可能有助于确定急性损伤与血清采样之间的时间间隔。与喂食充足饮食的绵羊相比，蛋白质摄入量受限的饮食与组织学损伤严重程度增加和肝功能下降有关。
