Ulvund M J
State Veterinary Research Station for Small Ruminants, Sandnes, Norway.
Acta Vet Scand. 1990;31(3):277-86. doi: 10.1186/BF03547540.
Changes in blood chemistry were examined in vitamin B12 deficient lambs which developed ovine white-liver disease (OWLD), and were compared with values of cobalt/B12 supplemented lambs on the same pastures, as well as clinically healthy, but sometimes B12 deficient, lambs on other pastures (H). In the OWLD group, signs of hepatic damage were seen concurrently with reduction in weight gain, or 1-3 weeks before, and comprised elevation of serum glutamate dehydrogenase (GLDH) and decrease of phospholipid and cholesterol. Drop of plasma glucose and elevation of gamma GT also came in the earlier phase of the disease. All other blood changes developed later, and were partly regarded as reflections of the inappetence or hepatic injury. The changes included a drop in packed cell volume (PCV) and mean corpuscular volume (MCV), elevation of serum iron, and reduction of total serum protein and urea. Generally Co/B12 supplementation prevented hepatic damage and normalized blood values. The clinically healthy H lambs also showed signs of hepatic damage, especially one year when they were B12 deficient, indicating that simple B12 deficiency causes a moderate liver damage as well. For diagnostic purposes, clinical pathology is recommended mainly on a flock basis.
对患羊白肝病（OWLD）的维生素B12缺乏羔羊的血液化学成分变化进行了检测，并与在相同牧场补充钴/维生素B12的羔羊以及在其他牧场临床健康但有时维生素B12缺乏的羔羊（H）的值进行了比较。在OWLD组中，肝脏损伤的迹象与体重增加减少同时出现，或在其前1至3周出现，包括血清谷氨酸脱氢酶（GLDH）升高、磷脂和胆固醇降低。血浆葡萄糖下降和γ-谷氨酰转移酶升高也出现在疾病的早期阶段。所有其他血液变化在后期出现，部分被视为食欲不振或肝脏损伤的反映。这些变化包括红细胞压积（PCV）和平均红细胞体积（MCV）下降、血清铁升高以及血清总蛋白和尿素降低。一般来说，补充钴/维生素B12可预防肝脏损伤并使血液值恢复正常。临床健康的H组羔羊也表现出肝脏损伤的迹象，尤其是在它们维生素B12缺乏的那一年，这表明单纯的维生素B12缺乏也会导致中度肝脏损伤。出于诊断目的，建议主要在群体基础上进行临床病理学检查。
