Boakes R A, Dwyer D M
Department of Psychology, University of Sydney, NSW, Australia.
Q J Exp Psychol B. 1997 May;50(2):129-48. doi: 10.1080/713932647.
To investigate factors affecting activity-based anorexia (ABA) or activity-stress (AS), rats were given 2-hr access to a running wheel immediately prior to their daily 1.5-hr food access during the light cycle. This produced a reduction in food intake, a steady increase in running, and a large drop in body weight with a prolonged delay before weight recovery began. Experiment 1 found that these effects were reduced in rats with prior experience of eating at this time of day. In contrast, prior experience of running in the wheel when on ad lib food enhanced these effects in Experiment 2, where a subsequent change for half the subjects to individual housing produced a further decrease in body weight. The latter factor was investigated from the outset of Experiment 3 and again individually housed rats showed greater weight loss than did group-housed rats. This experiment also found that in rats of the same age a low initial body weight predicts greater vulnerability to ABA. It was concluded that ABA results from activity-induced reduction of feeding, which prolongs adaptation to a new feeding schedule and is accentuated by social isolation.
为了研究影响基于活动的厌食症（ABA）或活动应激（AS）的因素，在光照周期中，于大鼠每日1.5小时的进食时间之前，立即给予它们2小时使用跑步轮的机会。这导致食物摄入量减少、跑步量稳步增加、体重大幅下降，且体重恢复开始前有长时间延迟。实验1发现，在一天中这个时间有进食经验的大鼠中，这些影响有所减轻。相比之下，在实验2中，当大鼠自由进食时在跑步轮上有跑步经验会增强这些影响，在该实验中，随后将一半的实验对象改为单独饲养导致体重进一步下降。从实验3一开始就对后一个因素进行了研究，再次发现单独饲养的大鼠比群居饲养的大鼠体重减轻得更多。该实验还发现，在同一年龄的大鼠中，初始体重较低预示着对ABA更易感性。得出的结论是，ABA是由活动引起的进食减少导致的，这会延长对新进食时间表的适应，并且社会隔离会加剧这种情况。
